RUPTURED ERYTHROCYTES INHIBIT THE OXIDATION OF MEMBRANES BY 15-HYDROPEROXY-EICOSATETRAENOIC ACID

被引：5

作者：

CALZADA, C ^{[1
]}

RICEEVANS, C ^{[1
]}

机构：

[1] UNITED MED & DENT SCH GUYS & ST THOMAS HOSP,DIV BIOCHEM,FREE RADICAL RES GRP,ST THOMAS ST,LONDON SE1 9RT,ENGLAND

来源：

FEBS LETTERS | 1993年 / 329卷 / 1-2期

关键词：

HEMOGLOBIN; HYDROPEROXIDE; ERYTHROCYTE MEMBRANE; LIPID PEROXIDATION; THIOL;

D O I：

10.1016/0014-5793(93)80204-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this study, the pro-oxidant effects of the hydroperoxide, 15-hydroperoxy-eicosatetraenoic acid (15-HPETE), on erythrocyte membranes and the modulation of the oxidation by haem proteins released from ruptured erythrocytes have been assessed. The results indicate that ruptured erythrocytes may act as an antioxidant in protecting membranes against oxidative stress induced by hydroperoxides and that it is the oxyhaemoglobin that is the active constituent of the protective mechanism. An important feature of the mechanism is the peroxidatic action of oxyhaemoglobin and its rate of reaction with 15-HPETE.

引用

页码：111 / 115

页数：5

共 22 条

[1] DETECTION OF FERRYL MYOGLOBIN IN THE ISOLATED ISCHEMIC RAT-HEART [J].