REACTION-KINETICS OF ALKYL EPOXIDES WITH DNA AND OTHER NUCLEOPHILES

被引：20

作者：

HEMMINKI, A ^{[1
]}

VAYRYNEN, T ^{[1
]}

HEMMINKI, K ^{[1
]}

机构：

[1] KAROLINSKA INST,NOVUM,CTR NUTR & TOXICOL,S-14152 HUDDINGE,SWEDEN

来源：

CHEMICO-BIOLOGICAL INTERACTIONS | 1994年 / 93卷 / 01期

关键词：

ALKYL EPOXIDE; 7-ALKYLGUANINE; DNA ADDUCT; EPOXIDE; 4-(P-NITROBENZYL)PYRIDINE;

D O I：

10.1016/0009-2797(94)90085-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

1,2-Epoxy alkanes from C3 to C8 were reacted with DNA, deoxyguanosine and 4-(p-nitrobenzyl) pyridine (NBP). DNA was hydrolyzed at neutral pH to release 7-alkylguanines. The products were analyzed by HPLC. The epoxides reacted largely according to the chain length, shorter epoxides being more reactive. Substitutions through carbon 1 predominated. Reactivity with NBP was almost equal between the epoxides.

引用

页码：51 / 58

页数：8

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