THE INFLUENCE OF IN-VIVO TREATMENT OF SKIN WITH LIPOSOMES ON THE TOPICAL ABSORPTION OF A HYDROPHILIC AND A HYDROPHOBIC DRUG IN-VITRO

被引：38

作者：

DUPLESSIS, J ^{[1
]}

WEINER, N ^{[1
]}

MULLER, DG ^{[1
]}

机构：

[1] UNIV MICHIGAN, COLL PHARM, ANN ARBOR, MI 48109 USA

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1994年 / 103卷 / 02期

关键词：

TOPICAL DELIVERY; LIPOSOME; HYDROPHILIC DRUG; HYDROPHOBIC DRUG;

D O I：

10.1016/0378-5173(94)90102-3

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Hairless mice were treated in vivo with empty phospholipid and `skin lipid' liposomes, respectively. The deposition of a hydrophobic drug (hydrocortisone) and a hydrophilic drug (inulin) was investigated in both treated and untreated skin. It was found that drugs should be encapsulated in liposomes or at least be administered together with the lipid, to achieve targeted drug delivery. Pretreatment of the skin with liposomes did not show the advantage of liposomally encapsulated drugs.

引用

页码：R1 / R5

页数：5

共 11 条

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