CATALYTIC-OXIDATION AND FLOW DETECTION OF ACETAMINOPHEN AT A DICYANOBIS(1,10-PHENANTHROLINE)IRON(II)-MODIFIED ELECTRODE

Dicyanobis(1,10-phenanthroline)iron(II)-modified glassy carbon electrodes were shown to exhibit an electrocatalytic response for the oxidation of acetaminophen with a decrease of 100 mV in the potential required. It can also inhibit the oxidation of ascorbic acid and uric acid. When used for amperometric monitoring of acetaminophen in a flowing stream, the coated electrode may permit detection at lower potentials compared with the naked surface. The method gives a linear range from 0.05 to 100 mu g ml(-1) and a detection limit of 0.02 mu g ml(-1) (signal-to-noise ratio = 2). The application of the method to the determination of acetaminophen in urine by LC is briefly described.