EXPRESSION OF PROGESTERONE-RECEPTOR FORM-A AND FORM-B MESSENGER-RNAS IN GYNECOLOGIC MALIGNANT-TUMORS

被引：47

作者：

FUJIMOTO, J

ICHIGO, S

HORI, M

NISHIGAKI, M

TAMAYA, T

机构：

[1] Department of Obstetrics and Gynecology, Gifu University School of Medicine, Gifu City

来源：

TUMOR BIOLOGY | 1995年 / 16卷 / 04期

关键词：

PROGESTERONE RECEPTOR FORMS A AND B; HUMAN; ENDOMETRIAL CANCER; CERVICAL CANCER; OVARIAN CANCER;

D O I：

10.1159/000217942

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

This study was designed to examine the biological implication of progesterone receptor (PR) forms A and B mRNA expressions in gynecologic cancers. The ratio of PR form A to form B in mRNA expression was approximately 1:1 in all endometria studied. The predominant expressions of form B transcript occurred in 6 out of 7 cases of advanced stages (stages III and IV) in ovarian cancers, in 5 out of 9 cases of cervical cancers, and in 5 out of 11 cases of endometrial cancers. In conclusions, the dominancy of PR form B mRNA expression might be associated with the expression of a malignant phenotype in gynecologic cancers, and advanced clinical stage in ovarian cancers, suggesting a biological marker of malignant phenotype in these three types of cancer cell.

引用

页码：254 / 260

页数：7

共 16 条

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