RELIEF OF CHOLESTATIC PRURITUS BY A NOVEL CLASS OF DRUGS - 5-HYDROXYTRYPTAMINE TYPE-3 (5-HT3) RECEPTOR ANTAGONISTS - EFFECTIVENESS OF ONDANSETRON

被引:121
作者
SCHWORER, H [1 ]
HARTMANN, H [1 ]
RAMADORI, G [1 ]
机构
[1] UNIV GOTTINGEN, DEPT MED, DIV GASTROENTEROL & ENDOCRINOL, D-37075 GOTTINGEN, GERMANY
关键词
ITCH; SEROTONIN; SEROTONIN RECEPTOR;
D O I
10.1016/0304-3959(94)00145-5
中图分类号
R614 [麻醉学];
学科分类号
100217 ;
摘要
The objective of the present study was to determine whether ondansetron, a specific serotonin type 3 receptor antagonist (5-HT3), relieves cholestatic pruritus in patients resistant to conventional antipruritic therapy (antihistamines and cholestyramine). In a placebo-controlled study the acute effect of an intravenous injection of ondansetron (4 mg, 8 mg) or placebo (NaCl solution) was tested in 10 patients (41-66 years of age; 4 men, 6 women) with cholestatic itch. A successful treatment was assessed when the intensity of itch was reduced by 50% or more within 2 h after injection of ondansetron. Intensity of itch was determined by the patients on a visual rating scale from 0 to 10. Ondansetron reduced or abolished pruritus within 30-60 min after injection. A 50% reduction of the intensity of itch was observed up to 6 h after injection of 8 mg. The effect was reproducible in the same patient. In conclusion ondansetron is effective in the treatment of cholestatic itch. Serotonin may participate in the generation and/or sensation of cholestatic pruritus.
引用
收藏
页码:33 / 37
页数:5
相关论文
共 27 条
[1]  
[Anonymous], [No title captured]
[2]   OBSERVATIONS ON CHEMICAL EXCITANTS OF CUTANEOUS PAIN IN MAN [J].
ARMSTRONG, D ;
DRY, RML ;
KEELE, CA ;
MARKHAM, JW .
JOURNAL OF PHYSIOLOGY-LONDON, 1953, 120 (03) :326-351
[3]   PRIMARY BILIARY-CIRRHOSIS - NEW THERAPEUTIC DIRECTIONS [J].
BERG, CL ;
GOLLAN, JL .
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 1992, 27 :43-49
[4]  
BERGASA NV, 1991, AM J GASTROENTEROL, V86, P1404
[5]   SUBHYPNOTIC DOSES OF PROPOFOL RELIEVE PRURITUS ASSOCIATED WITH LIVER-DISEASE [J].
BORGEAT, A ;
WILDERSMITH, OHG ;
MENTHA, G .
GASTROENTEROLOGY, 1993, 104 (01) :244-247
[6]   INFLUENCE OF A SPECIFIC 5-HT3 ANTAGONIST ON CARRAGEENAN-INDUCED HYPERALGESIA IN RATS [J].
ESCHALIER, A ;
KAYSER, V ;
GUILBAUD, G .
PAIN, 1989, 36 (02) :249-255
[7]   PRURITUS IN HEPATIC CHOLESTASIS - PATHOGENESIS AND THERAPY [J].
GARDEN, JM ;
OSTROW, JD ;
ROENIGK, HH .
ARCHIVES OF DERMATOLOGY, 1985, 121 (11) :1415-1420
[8]  
GHENT CN, 1979, YALE J BIOL MED, V52, P77
[9]   PERIPHERALLY ADMINISTERED SEROTONIN 5-HT3 RECEPTOR ANTAGONISTS REDUCE INFLAMMATORY PAIN IN RATS [J].
GIORDANO, J ;
ROGERS, L .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1989, 170 (1-2) :83-86
[10]   NEURAL MECHANISMS INVOLVED IN ITCH, ITCHY SKIN, AND TICKLE SENSATIONS [J].
GRAHAM, DT ;
GOODELL, H ;
WOLFF, HG .
JOURNAL OF CLINICAL INVESTIGATION, 1951, 30 (01) :37-49