INHIBITION OF GASTRIC-ACID SECRETION IN DOGS BY NEUROTENSIN

被引：147

作者：

ANDERSSON, S

CHANG, D

FOLKERS, K

ROSELL, S

机构：

[1] KAROLINSKA INST, DEPT PHARMACOL, S-10401 STOCKHOLM 60, SWEDEN

[2] UNIV TEXAS, INST BIOCHEM RES, AUSTIN, TX 78705 USA

来源：

LIFE SCIENCES | 1976年 / 19卷 / 03期

关键词：

D O I：

10.1016/0024-3205(76)90040-0

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Neurotensin is a tridecapeptide which was isolated from bovine hypothalamus. The action of synthetic neurotensin was studied on gastric acid secretion in dogs provided with gastric pouches. Infused neurotensin [i.v.], 50 ng .times. kg-1 .times. min-1, produced a considerable inhibition of pentagastrin stimulated gastric acid secretion. There was no sign of inhibition of histamine induced gastric acid secretion. Neurotensin, isolated from the CNS is a potent gastric secretory inhibitor and has a selective action in inhibiting gastric acid responses to pentagastrin but not to histamine.

引用

页码：367 / 370

页数：4