TREATMENT OF PERSISTENT POSTPARTUM HELLP SYNDROME WITH PLASMAPHERESIS

被引：22

作者：

KATZ, VL

WATSON, WJ

THORP, JM

HANSEN, W

BOWES, WA

机构：

[1] Division of Maternal and Fetal Medicine, Department of Obstetrics and Gynecology, University of North Carolina School of Medicine, Chapel Hill, North Carolina

来源：

AMERICAN JOURNAL OF PERINATOLOGY | 1992年 / 9卷 / 02期

关键词：

D O I：

10.1055/s-2007-994683

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Thrombocytopenia, associated with microangiopathic disease, is one characteristic of severe preeclampsia. Thrombocytopenia and intravascular hemolysis usually resolve by postpartum days 4 to 5. When thrombocytopenia secondary to microangiopathic disease persists, plasmapheresis may be used to arrest and reverse the process. Three patients over a 24-month period were successfully treated with plasma exchange with fresh frozen plasma. Several investigators who have cared for patients with persistent thrombocytopenia associated with preeclampsia have concluded that early plasmapheresis may be useful therapy. Plasma exchange should also be considered as a therapeutic option when clinical deterioration occurs due to microangiopathic disease.

引用

页码：120 / 122

页数：3

共 12 条

[1] Schwartz M.L., Possible role for exchange plasmapheresis with fresh frozen plasma for maternal indications in selected cases of preeclampsia and eclampsia, Obstet Gynecol, 67, pp. 136-139, (1986)
[2] Martin J.N., Files J.C., Blake P.G., Et al., Plasma exchange for preeclampsia, I. Postpartum use for persistently severe preeclampsia-eclampsia with HELLP syndrome. Am J Obstet Gynecol, 162, pp. 126-137, (1990)
[3] Katz V.L., Rozas L., Thorp J.M., Bowes W.A., The natural history of thrombocytopenia associated with preeclampsia, Am J Obstet Gynecol, 163, pp. 1142-1143, (1990)
[4] Watson W.J., Katz V.L., Bowes W.A., Plasmapheresis during pregnancy, Obstet Gynecol, 76, pp. 451-457, (1990)
[5] Use of blood components, FDA Drug Bull, 19, pp. 14-15, (1989)
[6] Kris M., White D.A., Treatment of eclampsia by plasma exchange, Plasma Ther Transfus Technol, 2, pp. 143-147, (1981)
[7] Segonds A., Louradour N., Suc J.M., Orfila C., Postpartum hemolytic uremic syndrome: A study of three cases with a review of the literature, Clin Nephrol, 12, pp. 229-242, (1979)
[8] Thysell H., Oxelius V., Norlin M., Successful treatment of hemolytic uremic syndrome and thrombotic thrombocytopenic purpura with fresh frozen plasma and plasma exchange, Acta Med Scand, 212, pp. 285-288, (1982)
[9] Caggiano V., Fernando L.P., Schneider J.M., Haesslein H.C., Watson-Williams E.J., Thrombotic thrombocytopenic purpura: Report of fourteen cases—occurrence during pregnancy and response to plasma exchange, J Clin Apheresis, 1, pp. 71-85, (1983)
[10] Gordon B.R., Saal S.D., Post-partum hemolytic uremic syndrome: Treatment with plasma exchange, Clin Exp Dial Apheresis, 7, pp. 169-176, (1983)

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