COMPLEXES OF CU(II) WITH ASN-SER-PHE-ARG-TYR-NH2 - AN EXAMPLE OF METAL ION-PROMOTED CONFORMATIONAL ORGANIZATION WHICH RESULTS IN EXCEPTIONALLY HIGH COMPLEX STABILITY

被引：56

作者：

BAL, W

KOZLOWSKI, H

KUPRYSZEWSKI, G

MACKIEWICZ, Z

PETTIT, L

ROBBINS, R

机构：

[1] UNIV LEEDS,SCH CHEM,LEEDS LS2 9JT,ENGLAND

[2] UNIV WROCLAW,INST CHEM,WROCLAW,POLAND

[3] UNIV GDANSK,DEPT CHEM,GDANSK,POLAND

来源：

JOURNAL OF INORGANIC BIOCHEMISTRY | 1993年 / 52卷 / 02期

关键词：

D O I：

10.1016/0162-0134(93)85024-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The pentapeptide fragment of ANF, Asn-Ser-Phe-Arg-Tyr-NH2, coordinates to Cu(II) using the same four nitrogen donor centers as simple pentapeptides such as pentaalanine yet the complexes are of much higher stability as a result of a highly organized side-chain structure which is present in the complex but absent from the free ligand.

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页码：79 / 87

页数：9

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