NEUROENDOCRINE DYSFUNCTION IN CLUSTER HEADACHE

被引：47

作者：

LEONE, M ^{[1
]}

PATRUNO, G ^{[1
]}

VESCOVI, A ^{[1
]}

BUSSONE, G ^{[1
]}

机构：

[1] IST NEUROCHIRURG C BESTA,CTR CEFALEE,VIA CELORIA 11,I-20133 MILAN,ITALY

来源：

CEPHALALGIA | 1990年 / 10卷 / 05期

关键词：

Cluster period; hypothalamic-pituitary axis; monoaminergic dysfunction; reduced TSH response; TRH test;

D O I：

10.1046/j.1468-2982.1990.1005235.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Current views on cluster headache pathogenesis indicate a primary central nervous system dysfunction, in particular a hypothalamic involvement. To confirm the hypothalamic involvement in cluster headache we evaluated the hypothalamic-pituitary axis responsiveness with the thyrotrophin releasing hormone (TRH) test. A dose of 200 μg of TRH was administered i.v. to nine healthy controls, 32 patients with cluster headache during cluster period and 16 in remission period. Delta maximum thyrotrophin (TSH) was significantly lower in patients with cluster headache during cluster period (p < 0.05 versus healthy controls and cluster headache patients in remission). No difference was observed between healthy controls and cluster headache patients in remission. A monoaminergic dysfunction at the hypothalamic level is hypothesized. © 1990, International Headache Society. All rights reserved.

引用

页码：235 / 239

页数：5

共 27 条

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