A CHLORIDE CHANNEL IN RAT AND HUMAN AXONS

被引：14

作者：

STRUPP, M

GRAFE, P

机构：

[1] Department of Physiology, University of Munich, Munich

来源：

NEUROSCIENCE LETTERS | 1991年 / 133卷 / 02期

关键词：

AXON; MYELINATED FIBER; PATCH CLAMP; SINGLE CHLORIDE CHANNEL; BACKGROUND CONDUCTANCE; RAT; HUMAN;

D O I：

10.1016/0304-3940(91)90578-H

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Current recordings from single chloride channels were obtained from excised and cell-attached patches of rat and human axons. In rat axons the channels showed an outwardly rectifying current-voltage relationship with a slope conductance of 33 pS at negative membrane potentials and 65 pS at positive potentials (symmetrical 150 mM CsCl). They were measurably permeable for cations (P(Na)/P(Cs)/P(Cl) = 0.1/0.2/1). Channel currents were independent of cytoplasmatic calcium concentration. Inactivation was not observed and gating was weakly voltage dependent. Cl- channels in human axons showed similar gating behavior but had a lower conductance.

引用

页码：237 / 240

页数：4

共 18 条

[1]

BAKER M, 1987, J PHYSIOL-LONDON, V383, P45

[2] SINGLE CHLORIDE-SELECTIVE CHANNELS ACTIVE AT RESTING MEMBRANE-POTENTIALS IN CULTURED RAT SKELETAL-MUSCLE [J].