LIQUID-CHROMATOGRAPHY MASS-SPECTROMETRY FOR THE DETERMINATION OF MEDETOMIDINE AND OTHER ANESTHETICS IN PLASMA

被引：23

作者：

KANAZAWA, H

NAGATA, Y

MATSUSHIMA, Y

TAKAI, N

UCHIYAMA, H

NISHIMURA, R

TAKEUCHI, A

机构：

[1] KYORITSU COLL PHARMACEUT SCI,SHIBAKOEN 1-5-30,MINATO KU,TOKYO 105,JAPAN

[2] UNIV TOKYO,INST IND SCI,MINATO KU,TOKYO 106,JAPAN

[3] UNIV TOKYO,FAC AGR,BUNKYO KU,TOKYO 113,JAPAN

来源：

JOURNAL OF CHROMATOGRAPHY | 1993年 / 631卷 / 1-2期

关键词：

D O I：

10.1016/0021-9673(93)80524-C

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A liquid chromatographic-atmospheric pressure chemical ionization mass spectrometric method is presented for the simultaneous determination of medetomidine and other anaesthetic drugs in solutions and dog plasma. The drugs examined were flumazenil, butorphanol, atropine, ketamine, xylazine, medetomidine, atipamezole and midazolam. The separation was carried out on a reversed-phase column using methanol-0.1 M ammonium acetate (3:2) as eluent.

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页码：215 / 220

页数：6

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