CEFTRIAXONE PLUS CONVENTIONAL OR SINGLE-DAILY DOSE AMIKACIN VERSUS CEFTAZIDIME AMIKACIN AS EMPIRIC THERAPY IN FEBRILE NEUTROPENIC PATIENTS

被引：20

作者：

LEONI, F

CIOLLI, S

PASCARELLA, A

FANCI, R

CAPORALE, R

FERRINI, PLR

机构：

[1] USL 10-D,CATTEDRA,FLORENCE,ITALY

[2] USL 10-D,DIV EMATOL,FLORENCE,ITALY

来源：

CHEMOTHERAPY | 1993年 / 39卷 / 02期

关键词：

GRANULOCYTOPENIC PATIENTS; CEFTRIXONE; CEFTAZIDIME; AMIKACIN;

D O I：

10.1159/000239118

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Results of antibiotic treatment in 144 febrile episodes during drug-induced granulocytopenia are reported. 63 episodes were treated with ceftazidime plus amikacin and 81 with ceftriaxone (CFX) using single daily doses combined with amikacin either divided in three doses (CFX-1 group) or administered as single doses (CFX-2 group). The response rates were 51, 80, and 57% respectively. In this study CFX was more effective than ceftazidime and amikacin provided better results when administered using the standard 8-hour scheduling.

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收藏

页码：147 / 152

页数：6

相关论文

共 17 条

[1] SINGLE DAILY DOSE TREATMENT OF SEVERE REFRACTORY INFECTIONS WITH CEFTRIAXONE - COST SAVINGS AND POSSIBLE PARENTERAL OUTPATIENT TREATMENT [J].

BAUMGARTNER, JD ;

GLAUSER, MP .

ARCHIVES OF INTERNAL MEDICINE, 1983, 143 (10) :1868-1873

[2] THE INVITRO ANTIBACTERIAL ACTIVITY OF CEFTRIAXONE IN COMPARISON WITH 9 OTHER ANTIBIOTICS [J].

EMMERSON, AM ;

LAMPORT, PA ;

REEVES, DS ;

BYWATER, MJ ;

HOLT, HA ;

WISE, R ;

ANDREWS, J ;

HALL, MJ .

CURRENT MEDICAL RESEARCH AND OPINION, 1985, 9 (07) :480-493

[3] HUMAN PHARMACOKINETICS AND DISTRIBUTION IN VARIOUS TISSUES OF CEFTRIAXONE [J].

FRASCHINI, F ;

BRAGA, PC ;

SCARPAZZA, G ;

SCAGLIONE, F ;

PIGNATARO, O ;

SAMBATARO, G ;

MARIANI, C ;

ROVIARO, GC ;

VAROLI, F ;

ESPOSTI, G .

CHEMOTHERAPY, 1986, 32 (03) :192-199

[4] CHALLENGING CONVENTIONAL AMINOGLYCOSIDE DOSING REGIMENS - THE VALUE OF EXPERIMENTAL-MODELS [J].

KAPUSNIK, JE ;

SANDE, MA .

AMERICAN JOURNAL OF MEDICINE, 1986, 80 (6B) :179-181

[5] CEFTAZIDIME MONOTHERAPY IS AS EFFECTIVE AS CEFTAZIDIME COMBINED WITH GENTAMICIN IN THE TREATMENT OF FEBRILE NEUTROPENIC PATIENTS [J].

KINSEY, SE ;

MACHIN, SJ ;

GOLDSTONE, AH .

JOURNAL OF HOSPITAL INFECTION, 1990, 15 :49-53

[6] SIGNIFICANCE OF ANTIMICROBIAL SYNERGISM FOR OUTCOME OF GRAM-NEGATIVE SEPSIS [J].

KLASTERSKY, J ;

MEUNIERCARPENTIER, F ;

PREVOST, JM .

AMERICAN JOURNAL OF THE MEDICAL SCIENCES, 1977, 273 (02) :157-167

[7] PROSPECTIVE RANDOMIZED COMPARISON OF 3 ANTIBIOTIC REGIMENS FOR EMPIRICAL THERAPY OF SUSPECTED BACTEREMIC INFECTION IN FEBRILE GRANULOCYTOPENIC PATIENTS [J].

KLASTERSKY, J ;

GLAUSER, MP ;

SCHIMPFF, SC ;

ZINNER, SH ;

GAYA, H .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1986, 29 (02) :263-270

[8] A COMPARATIVE-STUDY OF CEFTRIAXONE PLUS AMIKACIN, CEFTAZIDIME PLUS AMIKACIN AND IMIPENEM CILASTATIN IN THE EMPIRIC THERAPY OF FEBRILE GRANULOCYTOPENIC CANCER-PATIENTS [J].

LIU, CY ;

WANG, FD .

CHEMOTHERAPY, 1989, 35 :16-22

[9]

MARTINO P, 1990, HAEMATOLOGICA, V75, P69

[10]

PETRILLI AS, 1988, MEDIPRESS S, V4, P36