SELECTIVE DEESTERIFICATION STUDIES ON TAXANES - SIMPLE AND EFFICIENT HYDRAZINOLYSIS OF C-10 AND C-13 ESTER FUNCTIONALITIES

被引：21

作者：

DATTA, A ^{[1
]}

HEPPERLE, M ^{[1
]}

GEORG, GI ^{[1
]}

机构：

[1] UNIV KANSAS,DEPT MED CHEM,LAWRENCE,KS 66045

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1995年 / 60卷 / 03期

关键词：

D O I：

10.1021/jo00108a053

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[No abstract available]

引用

页码：761 / 763

页数：3

共 18 条

[1] UNEXPECTEDLY FACILE HYDROLYSIS OF THE 2-BENZOATE GROUP OF TAXOL AND SYNTHESES OF ANALOGS WITH INCREASED ACTIVITIES [J].

CHAUDHARY, AG ;

GHARPURE, MM ;

RIMOLDI, JM ;

CHORDIA, MD ;

GUNATILAKA, AAL ;

KINGSTON, DGI ;

GROVER, S ;

LIN, CM ;

HAMEL, E .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1994, 116 (09) :4097-4098

[2] STRUCTURE-ACTIVITY-RELATIONSHIPS OF TAXOL(R) - SYNTHESIS AND BIOLOGICAL EVALUATION OF C2 TAXOL ANALOGS [J].

CHEN, SH ;

FARINA, V ;

WEI, JM ;

LONG, B ;

FAIRCHILD, C ;

MAMBER, SW ;

KADOW, JF ;

VYAS, D ;

DOYLE, TW .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1994, 4 (03) :479-482

[3] INTERNAL NUCLEOPHILE ASSISTED SELECTIVE DEESTERIFICATION STUDIES ON BACCATIN-III - SYNTHESIS OF 2-DEBENZOYLBACCATIN-III AND 4-DEACETYLBACCATIN-III ANALOGS [J].

DATTA, A ;

JAYASINGHE, LR ;

GEORG, GI .

JOURNAL OF ORGANIC CHEMISTRY, 1994, 59 (16) :4689-4690

[4] A HIGHLY EFFICIENT, PRACTICAL APPROACH TO NATURAL TAXOL [J].

DENIS, JN ;

GREENE, AE ;

GUENARD, D ;

GUERITTEVOEGELEIN, F ;

MANGATAL, L ;

POTIER, P .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1988, 110 (17) :5917-5919

[5]

Georg G I., 1995, ACS S SERIES, V583

[6] SYNTHESIS OF BIOLOGICALLY-ACTIVE TAXOL ANALOGS WITH MODIFIED PHENYLISOSERINE SIDE-CHAINS [J].

GEORG, GI ;

CHERUVALLATH, ZS ;

HIMES, RH ;

MEJILLANO, MR ;

BURKE, CT .

JOURNAL OF MEDICINAL CHEMISTRY, 1992, 35 (22) :4230-4237

[7]

GEORG GI, 1994, EXPERT OPIN THER PAT, V4, P109

[8]

GEORG GI, 1995, IN PRESS TAXOL SCI A

[9] TAXOL AND TAXOTERE - DISCOVERY, CHEMISTRY, AND STRUCTURE-ACTIVITY-RELATIONSHIPS [J].

GUENARD, D ;

GUERITTEVOEGELEIN, F ;

POTIER, P .

ACCOUNTS OF CHEMICAL RESEARCH, 1993, 26 (04) :160-167

[10]

Hepperle Michael, 1994, Drugs of the Future, V19, P573

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