TRACHYSPIC ACID, A NEW METABOLITE PRODUCED BY TALAROMYCES-TRACHYSPERMUS, THAT INHIBITS TUMOR-CELL HEPARANASE - TAXONOMY OF THE PRODUCING STRAIN, FERMENTATION, ISOLATION, STRUCTURAL ELUCIDATION, AND BIOLOGICAL-ACTIVITY

被引：54

作者：

SHIOZAWA, H

TAKAHASHI, M

TAKATSU, T

KINOSHITA, T

TANZAWA, K

HOSOYA, T

FURUYA, K

TAKAHASHI, S

FURIHATA, K

SETO, H

机构：

[1] SANKYO CO LTD,BIOL RES LABS,SHINAGAWA KU,TOKYO 140,JAPAN

[2] SANKYO CO LTD,ANALYT & METAB RES LABS,SHINAGAWA KU,TOKYO 140,JAPAN

[3] SANKYO CO LTD,TSUKUBA RES LABS,TSUKUBA,IBARAKI 305,JAPAN

[4] UNIV TOKYO,DIV AGR & AGR LIFE SCI,BUNKYO KU,TOKYO 113,JAPAN

[5] UNIV TOKYO,INST MOLEC & CELLULAR BIOSCI,BUNKYO KU,TOKYO 113,JAPAN

来源：

JOURNAL OF ANTIBIOTICS | 1995年 / 48卷 / 05期

关键词：

D O I：

10.7164/antibiotics.48.357

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Trachyspic acid, a new metabolite that inhibited heparanase, was isolated from the culture broth of Talaromyces trachyspermus SANK 12191. Its structure was deduced from NMR spectral analyses and chemical reactions as a tricarboxylic acid derivative containing a spiroketal. The IC50 value of trachyspic acid against heparanase was 36 mu M.

引用

页码：357 / 362

页数：6

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