PALLADIUM-CATALYZED SYNTHESIS OF ARYLAMINES FROM ARYL HALIDES - MECHANISTIC STUDIES LEAD TO COUPLING IN THE ABSENCE OF TIN REAGENTS

被引：800

作者：

LOUIE, J ^{[1
]}

HARTWIG, JF ^{[1
]}

机构：

[1] YALE UNIV,DEPT CHEM,NEW HAVEN,CT 06520

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 21期

关键词：

D O I：

10.1016/0040-4039(95)00605-C

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The reaction of aryl halides with secondary amines in the presence of silylamide base and tri-o-tolyphopshine palladium complexes gives arylamine products. This process provides a convenient method for performing these hetero-cross coupling reactions without the necessity for forming tin amides and disposing of tin halides. This reaction follows from a mechanistic analysis of the coupling reaction with tin amides and occurs as a result of the cleavage of palladium aryl halide dimers with secondary amines.

引用

页码：3609 / 3612

页数：4

共 8 条

[1]

DRIVER MS, 1994, IN PRESS J AM CHEM S

[2]

GURAM AS, 1994, J AM CHEM SOC, P7901

[3]

GURAM AS, UNPUB

[4] PALLADIUM-CATALYZED AROMATIC AMINATION OF ARYL BROMIDES WITH N,N-DIETHYLAMINO-TRIBUTYLTIN [J].