CHIRAL BUILDING-BLOCKS FOR THE SYNTHESIS OF N-CONTAINING NATURAL-PRODUCTS .4. A FACILE METHOD FOR THE ASYMMETRIC-SYNTHESIS OF ENANTIOMERICALLY PURE 1-(2-FLUOROPHENYL)-ETHYLAMINE

被引：7

作者：

BRINGMANN, G

GEISLER, JP

机构：

[1] Institute of Organic Chemistry, University of Würzburg, D-8700 Würzburg, Am Hubland

来源：

JOURNAL OF FLUORINE CHEMISTRY | 1990年 / 49卷 / 01期

关键词：

D O I：

10.1016/S0022-1139(00)80363-2

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A simple, two-step-procedure for the synthesis of optically active (S)-1-(2-fluorophenyl)- ethylamine (1) is described. Starting from commercially available 2-fluoro-acetophenone (2), imination with (S)-1-phenyl-ethylamine (3), followed by stereoselective hydrogenation over Raney-nickel gives the secondary amine 5a. Subsequent regioselective hydrogenolytic cleavage of homogenous 5a yields enantiomerically pure 1. © 1990.

引用

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页码：67 / 73

页数：7

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