ATTENUATION OF VAGAL ACTION FOLLOWING SYMPATHETIC-STIMULATION IS MODULATED BY PREJUNCTIONAL ALPHA-2-ADRENOCEPTORS IN THE DOG

被引：12

作者：

HALL, GT ^{[1
]}

POTTER, EK ^{[1
]}

机构：

[1] UNIV NEW S WALES,SCH PHYSIOL & PHARMACOL,KENSINGTON,NSW 2033,AUSTRALIA

来源：

JOURNAL OF THE AUTONOMIC NERVOUS SYSTEM | 1990年 / 30卷 / 02期

基金：

英国医学研究理事会;

关键词：

Adrenoceptors; Neuropeptide Y; Vagus;

D O I：

10.1016/0165-1838(90)90136-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We examined the effect of the α2-adrenoceptor agonist clonidine and the α-adrenoceptor antagonist phentolamine on the attenuation of cardiac vagal action seen following stimulation of the cardiac sympathetic nerve. In the presence of phentolamine both the maximum percentage of inhibition of cardiac vagal action and the half-time to recovery were significantly increased. In the presence of clonidine both the maximum percentage of inhibition of vagal action and the half-time to recovery were significantly reduced. The results demonstrate that the inhibition of cardiac vagal action seen following sympathetic stimulation - an effect which is attributed to actions of the co-transmitter neuropeptide Y released during sympathetic stimulation - can be modulated by drugs acting on α-adrenoceptors. © 1990.

引用

页码：129 / 137

页数：9

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