HLA-A, B, C AND DR ANTIGENS IN NICKEL CONTACT SENSITIVITY

被引：16

作者：

MOZZANICA, N ^{[1
]}

RIZZOLO, L ^{[1
]}

VENERONI, G ^{[1
]}

DIOTTI, R ^{[1
]}

HEPEISEN, S ^{[1
]}

FINZI, AF ^{[1
]}

机构：

[1] OSPED FATEBENEFRATELLI OFTALMICO, DEPT IMMUNOHAEMATOL, MILAN, ITALY

来源：

BRITISH JOURNAL OF DERMATOLOGY | 1990年 / 122卷 / 03期

关键词：

D O I：

10.1111/j.1365-2133.1990.tb08278.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

The relationship between HLA antigens (A, B, C and DR) and nickel contact sensitivity was examined in 54 patients with contact allergy, as confirmed by an unequivocal positive patch-test reaction only to nickel. A control group was 320 healthy blood donors from the same geographical area as the patients. The HLA-A, B, C and DR antigens were typed using standard serological methods. HLA typing revealed a significant increase of HLA-DRw6 antigen in the patient group (corrected P < 0.025) and the relative risk for patients with DRw6 to develop nickel sensitivity was 3.32.

引用

页码：309 / 313

页数：5

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