APPLICATION OF C-11 LABELED NICOTINE IN THE MEASUREMENT OF HUMAN CEREBRAL BLOOD-FLOW AND OTHER PHYSIOLOGICAL-PARAMETERS

被引:13
作者
YOKOI, F
KOMIYAMA, T
ITO, T
HAYASHI, T
IIO, M
HARA, T
机构
[1] NATL NAKANO CHEST HOSP, NAKANO KU, TOKYO, JAPAN
[2] NIPPON MED COLL, CHIYODA KU, TOKYO 113, JAPAN
来源
EUROPEAN JOURNAL OF NUCLEAR MEDICINE | 1993年 / 20卷 / 01期
关键词
C-11 LABELED (R)NICOTINE; CEREBRAL BLOOD FLOW; POSITRON EMISSION TOMOGRAPHY;
D O I
10.1007/BF02261245
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Using positron emission tomography (PET), we measured the regional cerebral blood flow (rCBF) in five normal human subjects after intravenous injection of carbon-11 labelled (R)nicotine. The rCBF of the same subjects was measured by PET using the (CO2)-O-15 inhalation steady-state method. The distribution of C-11 activity in the brain after injection of C-11-(R)nicotine was almost equivalent to the CBF image obtained with the (CO2)-O-15 inhalation stead-state method. The kinetics of C-11-(R)nicotine in the brain was analysed using a two-compartment model consisting of vascular and brain tissue compartments. The rCBF values obtained with C-11-(R)nicotine were higher than with (CO2)-O-15 gas. The relatively long fixed distribution of C-11-(R)nicotine with a short uptake period allows stimulation studies by measurement of CBF to be performed with better photon flux and a longer imaging time than are possible with (H2O)-O-15.
引用
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页码:46 / 52
页数:7
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