THIENYLPYRAZOLOQUINOLINES WITH HIGH-AFFINITY TO BENZODIAZEPINE RECEPTORS - CONTINUOUS SHIFT FROM INVERSE AGONIST TO AGONIST PROPERTIES DEPENDING ON THE SIZE OF THE ALKYL SUBSTITUENT

被引：43

作者：

SHINDO, H

TAKADA, S

MURATA, S

EIGYO, M

MATSUSHITA, A

机构：

[1] SHIONOGI & CO LTD,DIV ORGAN CHEM,SHIONOGI RES LABS,FUKUSHIMA KU,OSAKA 553,JAPAN

[2] SHIONOGI & CO LTD,SHIONOGI RES LABS,DIV PHARMACOL,OSAKA 553,JAPAN

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1989年 / 32卷 / 06期

关键词：

D O I：

10.1021/jm00126a012

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：1213 / 1217

页数：5

共 20 条

[1]

BOREA PA, 1987, MOL PHARMACOL, V31, P334

[2] GABA REDUCES BINDING OF H-3-LABELED METHYL BETA-CARBOLINE-3-CARBOXYLATE TO BRAIN BENZODIAZEPINE RECEPTORS [J].

BRAESTRUP, C ;

NIELSEN, M .

NATURE, 1981, 294 (5840) :472-474

[3] LIGANDS FOR BENZODIAZEPINE RECEPTORS WITH POSITIVE AND NEGATIVE EFFICACY [J].

BRAESTRUP, C ;

HONORE, T ;

NIELSEN, M ;

PETERSEN, EN ;

JENSEN, LH .

BIOCHEMICAL PHARMACOLOGY, 1984, 33 (06) :859-862

[4]

CODDING PW, 1985, MOL PHARMACOL, V28, P178

[5]

FRYER RI, 1986, LIFE SCI, V39, P1947

[6]

Haefely W. E., 1985, ADV DRUG RES, V14, P165

[7] 2-HYDRAZINOTHIOPHENE-3-CARBONIC ACID-ESTERS [J].

HENTSCHEL, M ;

GEWALD, K .

JOURNAL FUR PRAKTISCHE CHEMIE-PRACTICAL APPLICATIONS AND APPLIED CHEMISTRY, 1974, 316 (05) :878-880

[8] SELECTIVE ANTAGONISTS OF BENZODIAZEPINES [J].

HUNKELER, W ;

MOHLER, H ;

PIERI, L ;

POLC, P ;

BONETTI, EP ;

CUMIN, R ;

SCHAFFNER, R ;

HAEFELY, W .

NATURE, 1981, 290 (5806) :514-516

[9] ACTIVATION OF BRAIN-FUNCTION BY S-135, A BENZODIAZEPINE RECEPTOR INVERSE AGONIST [J].

MATSUSHITA, A ;

KAWASAKI, K ;

MATSUBARA, K ;

EIGYO, M ;

SHINDO, H ;

TAKADA, S .

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 1988, 12 (06) :951-966

[10] BENZODIAZEPINE RECEPTOR - DEMONSTRATION IN CENTRAL NERVOUS-SYSTEM [J].

MOHLER, H ;

OKADA, T .

SCIENCE, 1977, 198 (4319) :849-851

← 1 2 →