CONTROL OF GROWTH IN NEONATAL PIG HEARTS

被引：23

作者：

BEINLICH, CJ ^{[1
]}

MORGAN, HE ^{[1
]}

机构：

[1] GEISINGER MED CLIN,SIGFRIED & JANET WEIS CTR RES,DANVILLE,PA 17822

来源：

MOLECULAR AND CELLULAR BIOCHEMISTRY | 1993年 / 119卷 / 1-2期

关键词：

CARDIAC HYPERTROPHY; NEONATAL HEART; RIBOSOME FORMATION; PROTEIN SYNTHESIS; ALPHA-1-ADRENERGIC AGONIST; CARDIAC MYOCYTES;

D O I：

10.1007/BF00926846

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The pig heart grows at a maximal rate in the first 2-3 days of life due to a volume overload imposed on the heart at birth. Rates of ribosome formation and protein synthesis cannot be further accelerated during in vitro perfusion with agents that increase cyclic AMP, that bind to alpha1-adrenergic receptors or that bind to angiotensin II receptors. Growth of the heart in vivo can be restrained by treatment with an angiotensin-converting enzyme inhibitor, enalapril maleate, or an angiotensin receptor antagonist, DuP 753. In the enalapril-treated heart, norepinephrine plus propranolol, but not angiotensin II, accelerated ribosome formation. Rapid growth of the left ventricle of pig heart during the first 10 days of life is due largely to eccentric hypertrophy.

引用

页码：3 / 9

页数：7

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