CONJUGATE ADDITION OF GRIGNARD-REAGENTS TO PARASUBSTITUTED NITROBENZENES

被引：9

作者：

BENTLEY, SJ ^{[1
]}

MILNER, DJ ^{[1
]}

机构：

[1] ICI PLC,SPECIALTIES RES CTR,MANCHESTER M9 3DA,LANCS,ENGLAND

来源：

JOURNAL OF ORGANOMETALLIC CHEMISTRY | 1993年 / 447卷 / 01期

关键词：

D O I：

10.1016/0022-328X(93)80265-D

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Nitrobenzenes bearing masked aldehyde, ketone and ketoester functions at the 4-position undergo conjugate addition with Grignard reagents in THF at -15-degrees-C. Sequential treatment of the 4-substituted nitrobenzenes with primary or secondary alkyl magnesium halides followed by 2,3-dichloro-5,6-dicyano-1,4-benzoquinone affords the corresponding 2-alkylated derivatives in 50-80% yields.

引用

页码：1 / 3

页数：3