DESIGN AND SYNTHESIS OF COSALANE, A NOVEL ANTI-HIV AGENT

被引：32

作者：

GOLEBIEWSKI, WM

BADER, JP

CUSHMAN, M

机构：

[1] PURDUE UNIV,DEPT MED CHEM & PHARMACOGNOSY,W LAFAYETTE,IN 47907

[2] NCI,DIV CANC TREATMENT,DEV THERAPEUT PROGRAM,ANTIVIRALS EVALUAT BRANCH,BETHESDA,MD 20852

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 08期

关键词：

D O I：

10.1016/S0960-894X(00)80053-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Cosalane, a novel anti-HIV agent having a dichlorodisalicylmethane unit linked to C-3 of cholestane by a three-carbon linker, was synthesized by a convergent route.

引用

页码：1739 / 1742

页数：4

共 18 条

[1] AURINTRICARBOXYLIC ACID AND EVANS BLUE REPRESENT 2 DIFFERENT CLASSES OF ANIONIC COMPOUNDS WHICH SELECTIVELY INHIBIT THE CYTOPATHOGENICITY OF HUMAN T-CELL LYMPHOTROPIC VIRUS TYPE-III LYMPHADENOPATHY-ASSOCIATED VIRUS [J].

BALZARINI, J ;

MITSUYA, H ;

DECLERCQ, E ;

BRODER, S .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1986, 136 (01) :64-71

[2] PREPARATION AND ANTI-HIV ACTIVITIES OF AURINTRICARBOXYLIC ACID FRACTIONS AND ANALOGS - DIRECT CORRELATION OF ANTIVIRAL POTENCY WITH MOLECULAR-WEIGHT [J].

CUSHMAN, M ;

WANG, PL ;

CHANG, SH ;

WILD, C ;

DECLERCQ, E ;

SCHOLS, D ;

GOLDMAN, ME ;

BOWEN, JA .

JOURNAL OF MEDICINAL CHEMISTRY, 1991, 34 (01) :329-337

[3] STRUCTURAL INVESTIGATION AND ANTI-HIV ACTIVITIES OF HIGH-MOLECULAR-WEIGHT ATA POLYMERS [J].

CUSHMAN, M ;

WANG, PL ;

STOWELL, JG ;

SCHOLS, D ;

DECLERCQ, E .

JOURNAL OF ORGANIC CHEMISTRY, 1992, 57 (26) :7241-7248

[4] SYNTHESIS OF THE COVALENT HYDRATE OF THE INCORRECTLY ASSUMED STRUCTURE OF AURINTRICARBOXYLIC ACID (ATA) [J].

CUSHMAN, M ;

KANAMATHAREDDY, S .

TETRAHEDRON, 1990, 46 (05) :1491-1498

[5] THE EFFICACY OF AZIDOTHYMIDINE (AZT) IN THE TREATMENT OF PATIENTS WITH AIDS AND AIDS-RELATED COMPLEX - A DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL [J].

FISCHL, MA ;

RICHMAN, DD ;

GRIECO, MH ;

GOTTLIEB, MS ;

VOLBERDING, PA ;

LASKIN, OL ;

LEEDOM, JM ;

GROOPMAN, JE ;

MILDVAN, D ;

SCHOOLEY, RT ;

JACKSON, GG ;

DURACK, DT ;

KING, D .

NEW ENGLAND JOURNAL OF MEDICINE, 1987, 317 (04) :185-191

[6] AZIDOTHYMIDINE ASSOCIATED WITH BONE-MARROW FAILURE IN THE ACQUIRED-IMMUNODEFICIENCY-SYNDROME (AIDS) [J].

GILL, PS ;

RARICK, M ;

BRYNES, RK ;

CAUSEY, D ;

LOUREIRO, C ;

LEVINE, AM .

ANNALS OF INTERNAL MEDICINE, 1987, 107 (04) :502-505

[7] HYDROLYSIS OF SUBSTITUTED ORTHO-CHLOROBENZOIC ACIDS - THE MECHANISM OF THE REACTION BETWEEN ORTHO-HALOGENOBENZOIC ACIDS AND NUCLEOPHILIC REAGENTS [J].

GOLDBERG, AA .

JOURNAL OF THE CHEMICAL SOCIETY, 1952, (NOV) :4368-4373

[8] HIV WITH REDUCED SENSITIVITY TO ZIDOVUDINE (AZT) ISOLATED DURING PROLONGED THERAPY [J].

LARDER, BA ;

DARBY, G ;

RICHMAN, DD .

SCIENCE, 1989, 243 (4899) :1731-1734

[9] INHIBITION OF THE INVITRO INFECTIVITY AND CYTOPATHIC EFFECT OF HUMAN LYMPHOTROPHIC-T VIRUS "TYPE-III/LYMPHADENOPATHY-ASSOCIATED VIRUS (HTLV-III/LAV) BY 2',3'-DIDEOXYNUCLEOSIDES [J].

MITSUYA, H ;

BRODER, S .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (06) :1911-1915

[10] 3'-AZIDO-3'-DEOXYTHYMIDINE (BW A509U) - AN ANTIVIRAL AGENT THAT INHIBITS THE INFECTIVITY AND CYTOPATHIC EFFECT OF HUMAN LYMPHOTROPIC-T VIRUS TYPE-III LYMPHADENOPATHY-ASSOCIATED VIRUS INVITRO [J].

MITSUYA, H ;

WEINHOLD, KJ ;

FURMAN, PA ;

STCLAIR, MH ;

LEHRMAN, SN ;

GALLO, RC ;

BOLOGNESI, D ;

BARRY, DW ;

BRODER, S .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (20) :7096-7100

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