AZA-ANNULATION AS A ROUTE TO HYDROXYLATED ALKALOID LIPIDS - THE SYNTHESIS OF (+/-)-PROSOPININE

被引：48

作者：

COOK, GR ^{[1
]}

BEHOLZ, LG ^{[1
]}

STILLE, JR ^{[1
]}

机构：

[1] MICHIGAN STATE UNIV,DEPT CHEM,E LANSING,MI 48824

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 11期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0040-4039(94)88315-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The total synthesis of (+/-)-prosopinine is described. Aza-annulation was used go generate the six-membered nitrogen heterocycle, stereochemical control was achieved through the use of the delta-lactam template, and homologation of the lactam introduced the alkyl chain substituent on the piperidine ring.

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页码：1669 / 1672

页数：4

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