REVERSIBLE ALOPECIA AFTER SINGLE-DOSE METHOTREXATE TREATMENT IN A PATIENT WITH ECTOPIC PREGNANCY

Objective: To report a case of a women who received a single 50 mg/m(2) dose of methotrexate (MTX) on two occasions for two separate ectopic pregnancies. After both treatments the patient experienced reversible alopecia. Design: Case report. Setting: Single human patient in a university-run clinic. Patients: A patient with an ectopic pregnancy presenting for treatment on two separate occasions. Interventions: A single dose of 50 mg/m(2) MTX given to the patient on both occasions. Main Outcome Measure: Loss of scalp hair. Results: On two separate occasions the patient lost a significant portion (33% to 50%) of her scalp hair. Conclusion: Even single-dose MTX as used for the treatment of ectopic pregnancy may induce alopecia in a susceptible patient.