DIPEPTIDYLPEPTIDASE-IV AND TRYPSIN-LIKE ENZYMATIC DEGRADATION OF HUMAN GROWTH-HORMONE RELEASING HORMONE IN PLASMA

被引：171

作者：

FROHMAN, LA ^{[1
]}

DOWNS, TR ^{[1
]}

HEIMER, EP ^{[1
]}

FELIX, AM ^{[1
]}

机构：

[1] HOFFMANN LA ROCHE INC,ROCHE RES CTR,DEPT PEPTIDE RES,NUTLEY,NJ 07110

来源：

JOURNAL OF CLINICAL INVESTIGATION | 1989年 / 83卷 / 05期

关键词：

D O I：

10.1172/JCI114049

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

引用

页码：1533 / 1540

页数：8

共 43 条

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[2]

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CHAPIN, LT ;

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ZINN, SA ;

TUCKER, HA .

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[5]

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[6]

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[7]

FELIX AM, 1986, PEPTIDES 1986, P481

[8]

Frohman L A, 1986, Methods Enzymol, V124, P371

[9] METABOLIC-CLEARANCE AND PLASMA DISAPPEARANCE RATES OF HUMAN PANCREATIC TUMOR-GROWTH HORMONE-RELEASING FACTOR IN MAN [J].

FROHMAN, LA ;

THOMINET, JL ;

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VANCE, ML ;

UDERMAN, H ;

RIVIER, J ;

VALE, W ;

THORNER, MO .

JOURNAL OF CLINICAL INVESTIGATION, 1984, 73 (05) :1304-1311

[10] RAPID ENZYMATIC DEGRADATION OF GROWTH-HORMONE RELEASING HORMONE BY PLASMA INVITRO AND INVIVO TO A BIOLOGICALLY INACTIVE PRODUCT CLEAVED AT THE NH2 TERMINUS [J].

FROHMAN, LA ;

DOWNS, TR ;

WILLIAMS, TC ;

HEIMER, EP ;

PAN, YCE ;

FELIX, AM .

JOURNAL OF CLINICAL INVESTIGATION, 1986, 78 (04) :906-913

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