PLASMA C-PEPTIDE RESPONSE TO ORAL GLUCOSE-LOAD IN HYPERTHYROIDISM

被引：4

作者：

BONORA, E ^{[1
]}

MANICARDI, V ^{[1
]}

ZENERE, M ^{[1
]}

MOGHETTI, P ^{[1
]}

COSCELLI, C ^{[1
]}

MUGGEO, M ^{[1
]}

机构：

[1] OSPED PARMA,DIV MED 1,I-43100 PARMA,ITALY

来源：

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION | 1990年 / 13卷 / 07期

关键词：

C-peptide; Hyperthyroidism; oral glucose load; pancreatic; β-cell;

D O I：

10.1007/BF03348624

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aim of the present study was to evaluate the pancreatic β cell response to oral glucose load in a group of patients with hyperthyroidism. For this purpose plasma C-peptide at fasting and after a 100 g oral glucose load was measured in 8 newly-diagnosed untreated hyperthyroid patients with fasting normoglycemia, and 8 sex-, age-, and weight-matched healthy controls. As compared to healthy subjects, patients with hyperthyroidism showed higher plasma glucose levels (incremental area 5405 ± 742 vs 2729 ± 539 mg/dl × 180 min, p < 0.05), and slightly reduced plasma C-peptide concentrations (incremental area 166 ± 12 vs 182 ± 36 pmol/ml × 180 min, p = NS) following oral glucose load. The ratios between plasma C-peptide and plasma glucose incremental areas were lower in hyperthyroid patients than in controls (3.66 ± 0.85 vs 10.41 ± 3.08, p < 0.05). These data suggest that hyperthyroidism is characterized by a decreased pancreatic β cell response to oral glucose load. © 1990, Italian Society of Endocrinology (SIE). All rights reserved.

引用

页码：555 / 558

页数：4

共 29 条

[1] GLUCOSE-TOLERANCE AND INSULIN-SECRETION IN HYPERTHYROIDISM [J].