RETINOIC ACID INDUCES LIVER BONE KIDNEY-TYPE ALKALINE-PHOSPHATASE GENE-EXPRESSION IN F9 TERATOCARCINOMA CELLS

被引：32

作者：

GIANNI, M

STUDER, M

CARPANI, G

TERAO, M

GARATTINI, E

机构：

来源：

BIOCHEMICAL JOURNAL | 1991年 / 274卷

关键词：

D O I：

10.1042/bj2740673

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

All-trans retinoic acid (RA) induces alkaline phosphatase (ALP) activity by 3-8-fold in murine F9 teratocarcinoma cells, in parallel with their differentiation towards primitive endoderm. The elevation of ALP activity is associated with increases in the amounts of liver/bone/kidney-type ALP protein and the respective transcript. These effects of RA are due to activation of ALP gene transcription rather than to an increase in the half-life of the mRNA. Induction of ALP mRNA does not require de novo protein synthesis, since it is not blocked by treatment with cycloheximide. Dibutyryl cyclic AMP, which is known to induce further differentiation of F9 cells from the primitive to the parietal endoderm, blocks the induction of ALP mRNA by RA.

引用

页码：673 / 678

页数：6

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