TRISOMY-8 AS A RECURRENT CLONAL ABNORMALITY IN BREAST-CANCER

被引：51

作者：

BULLERDIEK, J

LEUSCHNER, E

TAQUIA, E

BONK, U

BARTNITZKE, S

机构：

[1] UNIV BREMEN,CTR HUMAN GENET & GENET COUNSELING,W-2800 BREMEN 33,GERMANY

[2] CENT HOSP BREMEN N,INST PATHOL,BREMEN,GERMANY

来源：

CANCER GENETICS AND CYTOGENETICS | 1993年 / 65卷 / 01期

关键词：

D O I：

10.1016/0165-4608(93)90060-Y

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The results of cytogenetic investigations on one benign and 15 malignant breast tumors are described. Trisomy 7, 8, 18, and 21 and monosomy X occurred as clonal numerical aberrations, and inv(7)(q21q31) and t(4;12)(q21;p13) occurred as clonal structural aberrations. Only trisomy 8 was a recurrent karyotypic abnormality, however. Thus, we assumed that trisomy 8 as an early genetic change characterizes a subtype of ductal breast carcinomas.

引用

页码：64 / 67

页数：4

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