KERATINOCYTE EXPRESSION OF CLASS-II MHC ANTIGENS IN LONG-LASTING ALLERGIC PATCH TEST REACTIONS

被引：9

作者：

TODD, DJ ^{[1
]}

HANDLEY, J ^{[1
]}

WALSH, M ^{[1
]}

DOLAN, O ^{[1
]}

BURROWS, D ^{[1
]}

机构：

[1] ROYAL VICTORIA HOSP,DEPT DERMATOL,LEVEL SC,BELFAST BT12 6BA,NORTH IRELAND

来源：

CONTACT DERMATITIS | 1992年 / 26卷 / 01期

关键词：

LONG-LASTING ALLERGIC PATCH TEST REACTIONS; HLA-DR ANTIGENS; KERATINOCYTES; IMMUNOLOGICAL BASIS;

D O I：

10.1111/j.1600-0536.1992.tb00863.x

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

The keratinocyte expression of class II MHC antigens HLA-DR, DP and DQ was studied in 20 long-lasting allergic patch test reactions and 17 normal allergic patch tests reactions. No significant difference in the expression of these antigens in the 2 groups was detected. No 1 allergen was responsible for the majority of long-lasting allergic patch test reactions. The immunological mechanisms which may contribute to long-lasting allergic patch test reactions are discussed with reference to HLA-DR keratinocytes.

引用

页码：22 / 26

页数：5

共 15 条

[1] KERATINOCYTE HLA-DR EXPRESSION - THE RELATIONSHIP TO DERMAL LYMPHOCYTIC INFILTRATION [J].

BARKER, JNWN ;

OPHIR, J ;

MACDONALD, DM .

CLINICAL AND EXPERIMENTAL DERMATOLOGY, 1987, 12 (06) :397-399

[2] KERATINOCYTES AS INITIATORS OF INFLAMMATION [J].

BARKER, JNWN ;

MITRA, RS ;

GRIFFITHS, CEM ;

DIXIT, VM ;

NICKOLOFF, BJ .

LANCET, 1991, 337 (8735) :211-214

[3]

COOPER KD, 1990, CURR PROBL DERMATOL, V19, P69

[4]

DEPANFILIS G, 1990, IMMUNOLOGY, V69, P622

[5]

GASPARI AA, 1988, J IMMUNOL, V141, P2216

[6]

GASPARI AA, 1988, J IMMUNOL, V140, P2956

[7] KERATINOCYTE EXPRESSION OF MHC CLASS-II ANTIGENS IN ALLERGIC SENSITIZATION AND CHALLENGE REACTIONS AND IN IRRITANT CONTACT-DERMATITIS [J].

GAWKRODGER, DJ ;

CARR, MM ;

MCVITTIE, E ;

GUY, K ;

HUNTER, JAA .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1987, 88 (01) :11-16

[8]

KANERVA L, 1988, ACTA DERM-VENEREOL, V68, P116

[9] QUANTITATION OF DENDRITIC CELLS IN NORMAL AND ABNORMAL HUMAN-EPIDERMIS USING MONOCLONAL-ANTIBODIES DIRECTED AGAINST IA AND HTA ANTIGENS [J].

MACKIE, RM ;

TURBITT, ML .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1983, 81 (03) :216-220

[10] THE ROLE OF ADHESION MOLECULES, CHEMOTACTIC FACTORS, AND CYTOKINES IN INFLAMMATORY AND NEOPLASTIC SKIN-DISEASE - 1990 UPDATE [J].

NICKOLOFF, BJ ;

GRIFFITHS, CEM ;

BARKER, JNWN .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1990, 94 (06) :S151-S157

← 1 2 →