AMINES RELEASE FROM SCHIFF-BASES POLYMERS AND DIFFUSION FROM DOSAGE FORMS WITH EUDRAGIT RL IN ACIDIC MEDIUM

被引:10
作者
CHAFI, N [1 ]
KOLLI, M [1 ]
VERGNAUD, JM [1 ]
MONTHEARD, JP [1 ]
机构
[1] FAC SCI & TECHN ST ETIENNE, 23 RUE DR PAUL MICHELON, F-42023 ST ETIENNE, FRANCE
关键词
D O I
10.1002/app.1991.070431007
中图分类号
O63 [高分子化学(高聚物)];
学科分类号
070305 ; 080501 ; 081704 ;
摘要
Chloromethylstyrene 1 (mixture meta and para; 60/40) can be oxydized in corresponding aldehyde 2. Vinylbenzaldehyde 2 reacts with primary amines such as aniline, benzylamine, 2-phenylethylamine, 3-phenylpropylamine, and 2-aminopyridin to give Schiff bases that are polymerized in bulk with a radical initiator. Poly (vinyl benzaldehyde) 6 prepared from corresponding monomer 2 also reacts with primary amines to give polymeric Schiff bases. Hydrolyses of these polymeric amines have been carried out either in heterogeneous acidic medium or basic heterogeneous medium; a suitable percentage of amines has been released after some hours. Finally, a study of hydrolysis and of diffusion of released amines in a dosage form (Eudragit RL) has been also carried out with some polymeric Schiff bases.
引用
收藏
页码:1837 / 1847
页数:11
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