AMINES RELEASE FROM SCHIFF-BASES POLYMERS AND DIFFUSION FROM DOSAGE FORMS WITH EUDRAGIT RL IN ACIDIC MEDIUM

被引：10

作者：

CHAFI, N ^{[1
]}

KOLLI, M ^{[1
]}

VERGNAUD, JM ^{[1
]}

MONTHEARD, JP ^{[1
]}

机构：

[1] FAC SCI & TECHN ST ETIENNE, 23 RUE DR PAUL MICHELON, F-42023 ST ETIENNE, FRANCE

来源：

JOURNAL OF APPLIED POLYMER SCIENCE | 1991年 / 43卷 / 10期

关键词：

D O I：

10.1002/app.1991.070431007

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Chloromethylstyrene 1 (mixture meta and para; 60/40) can be oxydized in corresponding aldehyde 2. Vinylbenzaldehyde 2 reacts with primary amines such as aniline, benzylamine, 2-phenylethylamine, 3-phenylpropylamine, and 2-aminopyridin to give Schiff bases that are polymerized in bulk with a radical initiator. Poly (vinyl benzaldehyde) 6 prepared from corresponding monomer 2 also reacts with primary amines to give polymeric Schiff bases. Hydrolyses of these polymeric amines have been carried out either in heterogeneous acidic medium or basic heterogeneous medium; a suitable percentage of amines has been released after some hours. Finally, a study of hydrolysis and of diffusion of released amines in a dosage form (Eudragit RL) has been also carried out with some polymeric Schiff bases.

引用

页码：1837 / 1847

页数：11

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