CONGO RED INHIBITION OF SCRAPIE AGENT REPLICATION

被引：115

作者：

CAUGHEY, B

ERNST, D

RACE, RE

机构：

来源：

JOURNAL OF VIROLOGY | 1993年 / 67卷 / 10期

关键词：

D O I：

10.1128/JVI.67.10.6270-6272.1993

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Congo red inhibits the accumulation of protease-resistant PrP in scrapie-infected mouse neuroblastoma cells. Here we show that Congo red also inhibits the replication of scrapie infectivity in these cells. This observation is consistent with the idea that protease-resistant PrP is a vital component of the scrapie agent or that agent replication depends on the presence of protease-resistant PrP in the cell.

引用

页码：6270 / 6272

页数：3

共 24 条

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