SYNTHESIS AND UTILITY OF 5-THIOCYANATO DEOXYURIDINE AND URIDINE PHOSPHORAMIDITES AS MASKED SYNTHONS

被引：24

作者：

BRADLEY, DH ^{[1
]}

HANNA, MM ^{[1
]}

机构：

[1] UNIV OKLAHOMA, DEPT BOT & MICROBIOL, NORMAN, OK 73019 USA

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 42期

关键词：

D O I：

10.1016/S0040-4039(00)60938-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

5-Thiocyanato-2-deoxyuridine and 5-thiocyanato-uridine phosphoramidites have been synthesized and incorporated into DNA and RNA trimers via automated methodology. The SCN group has been removed with DTT treatment, and a photocrosslinking aryl azide has been added to the DNA trinucleotide through the resulting thiol group.

引用

页码：6223 / 6226

页数：4

共 9 条

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