CLOSE LINKAGE OF THE DOMINANT CATARACT MUTATIONS (CAT-2) WITH IDH-1 AND CRYGE ON MOUSE CHROMOSOME-1

被引：19

作者：

LOSTER, J ^{[1
]}

PRETSCH, W ^{[1
]}

SANDULACHE, R ^{[1
]}

SCHMITTJOHN, T ^{[1
]}

LYON, MF ^{[1
]}

GRAW, J ^{[1
]}

机构：

[1] MRC,RADIOBIOL UNIT,DIDCOT OX11 0RD,OXON,ENGLAND

来源：

GENOMICS | 1994年 / 23卷 / 01期

关键词：

D O I：

10.1006/geno.1994.1484

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The murine dominant gene Cat-2 was located on chromosome 1 between the loci of fuzzy and leaden. Subsequent linkage analysis revealed one recombinant between Cat-2(t) and isocitrate dehydrogenase-1, and one between Cat-2(t) and gamma E-crystallin among 338 offspring in three-point backcrosses. The resulting genetic distance between the loci is 0.3 +/- 0.3 cM. The very close linkage between the Cat-2 and the gamma-crystallin gene cluster together with the finding of reduced gamma-crystallin transcripts in mutant lenses suggest strongly that the gamma-crystallin genes may be candidate genes for the Cat-2 mutations. (C) 1994 Academic Press, Inc.

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页码：240 / 242

页数：3

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