RECENT DEVELOPMENTS IN THE CELL BIOLOGY OF GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR AND GRANULOCYTE COLONY-STIMULATING FACTOR - ACTIVITIES ON ENDOTHELIAL-CELLS

被引：33

作者：

BUSSOLINO, F ^{[1
]}

COLOTTA, F ^{[1
]}

BOCCHIETTO, E ^{[1
]}

GUGLIELMETTI, A ^{[1
]}

MANTOVANI, A ^{[1
]}

机构：

[1] MARIO NEGRI INST PHARMACOL RES,I-20157 MILAN,ITALY

来源：

INTERNATIONAL JOURNAL OF CLINICAL & LABORATORY RESEARCH | 1993年 / 23卷 / 01期

关键词：

GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; GRANULOCYTE-COLONY STIMULATING FACTOR; ENDOTHELIUM; ANGIOGENESIS; VASCULAR TUMOR; BONE MARROW;

D O I：

10.1007/BF02592273

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Granulocyte-macrophage colony-stimulating factor and granulocyte colony-stimulating factor were considered as growth and differentiation factors restricted to hematopoietic cells. It was recently found that non-hematopoietic cells, including endothelial cells, respond to these cytokines. In this review we describe their effects on endothelial cells, underlining their role in the behavior and survival of the microenvironment of bone marrow, in the angiogenesis process related to the progression of solid tumors and of vascular tumors, and in the homing of lymphocytes.

引用

页码：8 / 12

页数：5

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