CHICKEN NFI/TGGCA PROTEINS ARE ENCODED BY AT LEAST 3 INDEPENDENT GENES - NFI-A, NFI-B AND NFI-C WITH HOMOLOGS IN MAMMALIAN GENOMES

被引：170

作者：

RUPP, RAW ^{[1
]}

KRUSE, U ^{[1
]}

MULTHAUP, G ^{[1
]}

GOBEL, U ^{[1
]}

BEYREUTHER, K ^{[1
]}

SIPPEL, AE ^{[1
]}

机构：

[1] UNIV HEIDELBERG,ZENTRUM MOLEK BIOL,W-6900 HEIDELBERG,GERMANY

来源：

NUCLEIC ACIDS RESEARCH | 1990年 / 18卷 / 09期

关键词：

D O I：

10.1093/nar/18.9.2607

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Chicken TGGCA proteins belong to the ubiquitous, eukaryotic family of NFI-like nuclear proteins, which share an identical DNA binding specificity. They are involved in viral and cellular aspects of transcriptlonal regulation and they are capable of stimulating Adenovirus initiation of replication. Using microsequencing data from peptides of isolated proteins and PCR supported cloning, we have derived four cDNAs for NFI/TGGCA proteins, which are encoded by three separate chicken genes. Sequence alignments of NFI proteins from chicken and various mammalian species provide evidence for a common genetic equipment among higher eukaryotes, in which several related genes, employing each differential RNA splicing generate an unexpectedly large family of diverse NFI proteins. The extensive similarity of the amino acid sequence throughout the complete coding regions between products of the same gene type in different species indicates a uniform selection pressure on all protein parts, also on those outside the DNAbinding domain. © 1990 Oxford University Press.

引用

页码：2607 / 2616

页数：10

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