SYNTHESIS OF THYMINE NUCLEOSIDES DERIVED FROM 1-DEOXY-D-PSICOFURANOSE

被引：20

作者：

FAIVREBUET, V ^{[1
]}

GROUILLER, A ^{[1
]}

DESCOTES, G ^{[1
]}

机构：

[1] UNIV LYON 1,CHIM ORGAN LAB 2,CNRS,URA 463,BAT 308,43 BLVD 11 NOVEMBRE 1918,F-69622 VILLEURBANNE,FRANCE

来源：

NUCLEOSIDES & NUCLEOTIDES | 1992年 / 11卷 / 09期

关键词：

D O I：

10.1080/07328319208021356

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The use of D-(+)-ribonic gamma-lactone 1a,b as a chiral synthon leads to an efficient synthesis of the ketose 1-deoxy-D-psicofuranose 2a,b. Condensation of the corresponding acetyl derivative 3a,b with silylated thymine, followed by deprotection of 4a,b, affords an anomeric mixture of ketosyl nucleoside 6 (predominately the beta-anomer) in an improved overall yield of 49 %.

引用

页码：1651 / 1660

页数：10

共 15 条

[1] SYNTHESIS AND EVALUATION OF A SERIES OF 1-(3-ALKYL-2,3-DIDEOXY-ALPHA,BETA-D-ERYTHRO-PENTOFURANOSYL)THYMINES [J].