THE ACUTE AND CHRONIC EFFECTS OF (+) AND (-) OXAPROTILINE UPON MELATONIN SECRETION IN NORMAL SUBJECTS

被引：16

作者：

PALAZIDOU, E ^{[1
]}

SKENE, D ^{[1
]}

ARENDT, J ^{[1
]}

EVERITT, B ^{[1
]}

CHECKLEY, SA ^{[1
]}

机构：

[1] UNIV SURREY,DEPT BIOCHEM,GUILDFORD GU2 5XH,SURREY,ENGLAND

来源：

PSYCHOLOGICAL MEDICINE | 1992年 / 22卷 / 01期

关键词：

D O I：

10.1017/S0033291700032736

中图分类号：

B849 [应用心理学];

学科分类号：

040203 ;

摘要：

Ten healthy male subjects were treated for three weeks with (+)oxaprotiline, a selective inhibitor of noradrenaline (NA) uptake and with (-)oxaprotiline which does not inhibit NA uptake. Plasma melatonin concentrations were measured throughout the night at 0, 1, 7 and 21 days and were higher during treatment with (+)oxaprotiline than with (-)oxaprotiline for the entire three weeks of treatment. Since NA stimulates the production and secretion of melatonin, these results are consistent with a sustained increase in noradrenergic activity within the pineal, during 21 days of treatment with an effective NA uptake inhibitor.

引用

页码：61 / 67

页数：7

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