MODULATION OF MHC GENE-EXPRESSION BY GLUCOCORTICOID HORMONES

被引：6

作者：

SCUDELETTI, M ^{[1
]}

LANZA, L ^{[1
]}

CONTINI, P ^{[1
]}

PUPPO, F ^{[1
]}

INDIVERI, F ^{[1
]}

机构：

[1] UNIV GENOA,DEPT INTERNAL MED CLIN METHOD,I-16126 GENOA,ITALY

来源：

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY | 1992年 / 99卷 / 2-4期

关键词：

GLUCOCORTICOIDS; MHC; HLA; INTERFERON; LYMPHOCYTES; MELANOMA;

D O I：

10.1159/000236268

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

The effects of the glucocorticoid hormones prednisone (PDN) and deflazacort (DFC) on MHC gene products membrane expression and mRNA level were evaluated on peripheral blood lymphocytes and on the melanoma M14 cell line. The modulatory effect of the association of PDN and DFC with interferon-gamma was also evaluated. PDN and DFC inhibited MHC gene expression in lymphocytes and M14 cells both on the cell membrane and at the mRNA level. Interferon-gamma was able to counteract this inhibitory effect. These results may contribute to clarify the role played by glucocorticoid hormones in the modulation of immune responses.

引用

页码：295 / 301

页数：7