A NOVEL BROMOPYRROLE ALKALOID FROM THE SPONGE AGELAS-LONGISSIMA WITH ANTISEROTONERGIC ACTIVITY

被引：37

作者：

CAFIERI, F

FATTORUSSO, E

MANGONI, A

TAGLIALATELASCAFATI, O

CARNUCCIO, R

机构：

[1] DIPARTIMENTO CHIM SOSTANZE NAT, I-80131 NAPLES, ITALY

[2] DIPARTIMENTO FARMACOL SPERIMENTALE, I-80131 NAPLES, ITALY

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 08期

关键词：

D O I：

10.1016/0960-894X(95)00116-B

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Agelongine (1), a novel bromopyrrole alkaloid containing a pyridinium ring in place of the imidazole nucleus, usually found in Agelas alkaloids, has been isolated from the Caribbean sponge Agelas longissima, and its structure established by spectroscopic analysis and chemical degradation. Agelongine exhibited an antiserotonergic activity tested in vitro on the rat stomach fundus strip.

引用

页码：799 / 804

页数：6

共 14 条

[1] SENSITIVITY-ENHANCED TWO-DIMENSIONAL HETERONUCLEAR SHIFT CORRELATION NMR-SPECTROSCOPY
BAX, A
SUBRAMANIAN, S
[J]. JOURNAL OF MAGNETIC RESONANCE, 1986, 67 (03) : 565 - 569
[2] ION SPRAY INTERFACE FOR COMBINED LIQUID CHROMATOGRAPHY/ATMOSPHERIC PRESSURE IONIZATION MASS-SPECTROMETRY
BRUINS, AP
COVEY, TR
HENION, JD
[J]. ANALYTICAL CHEMISTRY, 1987, 59 (22) : 2642 - 2646
[3] HIGH-RESOLUTION INVESTIGATION OF PROTON COUPLED AND DECOUPLED C-13 FT NMR-SPECTRA OF N-15-PYRROLE
BUNDGAARD, T
JAKOBSEN, HJ
RAHKAMAA, EJ
[J]. JOURNAL OF MAGNETIC RESONANCE, 1975, 19 (03) : 345 - 356
[4] CHRISTOPHERSEN, 1985, ALKALOIDS, V24
[5] NEW BROMO-PYRROLE DERIVATIVES FROM SPONGE AGELAS-OROIDES
FORENZA, S
MINALE, L
RICCIO, R
[J]. JOURNAL OF THE CHEMICAL SOCIETY D-CHEMICAL COMMUNICATIONS, 1971, (18): : 1129 - &
[6] REINVESTIGATION INTO STRUCTURE OF OROIDIN, A BROMOPYRROLE DERIVATIVE FROM MARINE SPONGE
GARCIA, EE
BENJAMIN, LE
FRYER, RI
[J]. JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1973, (03) : 78 - 79
[7] ALPHA-ADRENOCEPTOR BLOCKING ACTION OF HYMENIN, A NOVEL MARINE ALKALOID
KOBAYASHI, J
NAKAMURA, H
OHIZUMI, Y
[J]. EXPERIENTIA, 1988, 44 (01): : 86 - 87
[8] A NOVEL ANTAGONIST OF SEROTONERGIC RECEPTORS, HYMENIDIN, ISOLATED FROM THE OKINAWAN MARINE SPONGE HYMENIACIDON SP
KOBAYASHI, J
OHIZUMI, Y
NAKAMURA, H
HIRATA, Y
[J]. EXPERIENTIA, 1986, 42 (10): : 1176 - 1177
[9] A POTENT ACTOMYOSIN ATPASE ACTIVATOR FROM THE OKINAWAN MARINE SPONGE AGELAS CF NEMOECHINATA
KOBAYASHI, J
TSUDA, M
OHIZUMI, Y
[J]. EXPERIENTIA, 1991, 47 (03): : 301 - 304
[10] AGELIFERINS, POTENT ACTOMYOSIN ATPASE ACTIVATORS FROM THE OKINAWAN MARINE SPONGE AGELAS SP
KOBAYASHI, J
TSUDA, M
MURAYAMA, T
NAKAMURA, H
OHIZUMI, Y
ISHIBASHI, M
IWAMURA, M
OHTA, T
NOZOE, S
[J]. TETRAHEDRON, 1990, 46 (16) : 5579 - 5586

← 1 2 →