A NOVEL GENE, TRANSLIN, ENCODES A RECOMBINATION HOTSPOT BINDING-PROTEIN ASSOCIATED WITH CHROMOSOMAL TRANSLOCATIONS

被引：187

作者：

AOKI, K

SUZUKI, K

SUGANO, T

TASAKA, T

NAKAHARA, K

KUGE, O

OMORI, A

KASAI, M

机构：

[1] NATL INST HLTH,DEPT IMMUNOL,SHINJUKU KU,TOKYO 162,JAPAN

[2] NATL INST HLTH,DEPT PATHOL,SHINJUKU KU,TOKYO 162,JAPAN

[3] NATL INST HLTH,DEPT BIOCHEM & CELL BIOL,SHINJUKU KU,TOKYO 162,JAPAN

[4] UNIV TOKYO,SCH MED,DEPT INTERNAL MED,BUNKYO KU,TOKYO 113,JAPAN

[5] KYORIN UNIV,SCH MED,DEPT CLIN PATHOL,MITAKA 181,TOKYO,JAPAN

[6] MITSUBISHI KASEI INST LIFE SCI,MACHIDA,TOKYO 194,JAPAN

来源：

NATURE GENETICS | 1995年 / 10卷 / 02期

关键词：

D O I：

10.1038/ng0695-167

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We have identified a novel gene, Translin, encoding a protein which specifically binds to consensus sequences at breakpoint junctions of chromosomal translocations in many cases of lymphoid malignancies. The encoded protein, Translin, is a previously undescribed type with no significant similarity to known proteins. In the native-form, Translin polypeptides form a multimeric structure which is responsible for its DNA binding activity. Nuclear localization of Translin is limited to lymphoid cell lines, raising the intriguing possibility that nuclear transport of Translin is regulated in a physiologically significant way such that active nuclear transport is associated with the lymphoid specific process known as Ig/TCR gene rearrangement.

引用

页码：167 / 174

页数：8

共 63 条

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[10] 14)(p32

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