EFFECT OF INTERFERON-GAMMA AND TUMOR NECROSIS FACTOR-ALPHA ON LYMPHOEPITHELIAL INTERACTIONS WITHIN THYMIC NURSE CELLS

被引：22

作者：

DEFRESNE, MP ^{[1
]}

HUMBLET, C ^{[1
]}

RONGY, AM ^{[1
]}

GREIMERS, R ^{[1
]}

BONIVER, J ^{[1
]}

机构：

[1] STATE UNIV LIEGE,DEPT PATHOL,PATHOL ANAT & CYTOPATHOL LAB,B-4000 LIEGE,BELGIUM

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 1990年 / 20卷 / 02期

关键词：

D O I：

10.1002/eji.1830200229

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Isolated thymic nurse cells (TNC) represent a specialized microenvironment in vivo where thymocytes interact specifically with subcapsular epithelial cells. They are thought to play a critical role in the process of T cell differentiation. We demonstrate that recombinant murine interferon‐γ and recombinant human tumor necrosis factor‐α can act on these interactions: they stimulate TNC‐derived epithelial cells to establish interactions with thymocytes in vitro and to form new lymphoepithelial complexes. This phenomenon is partially inhibited by anti‐la monoclonal antibodies. Implications of these findings for normal intrathymic differentiation are discussed. Copyright © 1990 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim

引用

页码：429 / 432

页数：4

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