SYNTHESIS OF PYRIDO[2,3,4-KL]ACRIDINES - A BUILDING BLOCK FOR THE SYNTHESIS OF PYRIDOACRIDINE ALKALOIDS

被引：16

作者：

GELLERMAN, G ^{[1
]}

RUDI, A ^{[1
]}

KASHMAN, Y ^{[1
]}

机构：

[1] TEL AVIV UNIV, SCH CHEM, IL-69978 TEL AVIV, ISRAEL

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 38期

关键词：

D O I：

10.1016/S0040-4039(00)61150-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two new syntheses have been developed for the preparation of substituted pyrido[2,3,4-kl]acridines. The first synthesis involves a Skraup reaction and a nitrene insertion whereas the second includes a new pyridine ring synthesis starting from a 1-amino group on acridine and taking advantage of the active 9-position of the latter heterocycle.

引用

页码：5577 / 5580

页数：4

共 20 条

[1]

Cadogan J. I. G, 1969, SYNTHESIS-STUTTGART, P11

[2]

CARROLL AR, 1990, J ORG CHEM, V55, P4427

[3] DIPLAMINE, A CYTO-TOXIC POLYAROMATIC ALKALOID FROM THE TUNICATE DIPLOSOMA SP [J].