MOLECULAR ANALYSIS OF A CYTOCHROME-P450 GENE OF FAMILY-4 ON THE DROSOPHILA X-CHROMOSOME

被引：47

作者：

GANDHI, R ^{[1
]}

VARAK, E ^{[1
]}

GOLDBERG, ML ^{[1
]}

机构：

[1] CORNELL UNIV,GENET & DEV SECT,ITHACA,NY 14853

来源：

DNA AND CELL BIOLOGY | 1992年 / 11卷 / 05期

关键词：

D O I：

10.1089/dna.1992.11.397

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A member of the cytochrome P450 superfamily has been identified within region 2D of the Drosophila X chromosome. The sequence of this gene shows strongest homology with P450 family 4 genes, and has thus been named CYP4D1 in accordance with convention. This P450 gene is expressed throughout Drosophila development, with the highest levels of transcript accumulation occurring during late larval stages. A fragment of Drosophila genomic DNA including the CYP4D1 gene has been reintroduced into the germ line by P-element-mediated transformation. This transduced fragment does not rescue any of the lethal mutations that have been identified in this genetically well-characterized region of the Drosophila genome.

引用

页码：397 / 404

页数：8

共 40 条

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[2]

ALATORTSEV V, 1985, DROS INFORM SERV, V61, P24

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