NUTRIENT-INDUCED THERMOGENESIS (NIT) FOLLOWING AMINO-ACID INFUSION

被引：5

作者：

SAKAUE, M ^{[1
]}

TSUJINAKA, T ^{[1
]}

KIDO, Y ^{[1
]}

HAYASHIDA, Y ^{[1
]}

YANO, M ^{[1
]}

HOMMA, T ^{[1
]}

IIJIMA, S ^{[1
]}

KAN, K ^{[1
]}

EBISUI, T ^{[1
]}

MORI, T ^{[1
]}

机构：

[1] OSAKA UNIV,SCH MED,DEPT SURG 2,SUITA,OSAKA 565,JAPAN

来源：

CLINICAL NUTRITION | 1994年 / 13卷 / 02期

关键词：

D O I：

10.1016/0261-5614(94)90070-1

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Nutrient-induced thermogenesis (NIT) induced by parenteral infusion of amino acid (AA) mixtures of different composition and of the same AA mixtures given via different routes (parenteral or intraportal infusion) were investigated in rats using a small animal indirect calorimeter. When 8 different AA solutions of differing composition but with the same total concentration were infused parenterally, both standard NIT (each AA is assumed to generate 3.28 kcal/g) and specific NIT (heat energy of each AA is calculated assuming that it is oxidized to carbon dioxide and water, and metabolised to urea and sulphuric acid) values of the leucine (Leu)-rich and the glycine (Gly)-rich solutions were significantly greater than those of the control solution. Removal of Leu or Gly from the respective AA solutions reversed the increase of both NIT values down to control levels. When the parenteral and portal infusion routes were used in one rat, both NIT values for parenteral infusion of the Leu-rich solution were again significantly greater than those of the control. Likewise, both NIT values for intraportal infusion of the Leu-rich solution were also significantly greater than those of the control. However, no difference in NIT values was found between parenteral and portal infusion of either solution. The result of this study indicated that Leu and Gly may be thermogenic AAs, and the thermogenic effect of Leu is not dependent upon the route of infusion.

引用

页码：116 / 122

页数：7

共 17 条

[1]

Vernet, Nacht, Jequier, β-Adrenergic blockade and intravenous nutrient-induced thermogenesis in lean and obese women, Am J Physiol, 253, pp. E65-E70, (1987)

[2]

Vernet, Christin, Shutz, Enteral versus parenteral nutrition Comparison of energy metabolism in healthy subjects, Am J Physiol, 250, pp. E47-E54, (1986)

[3]

Arnold, Shipley, Scott, Thermic effect of parenteral nutrition in septic and nonseptic indivisuals, Am J Clin Nutr, 50, pp. 853-860, (1989)

[4]

Flatt, The biochemistry of energy expenditure, Recent Avandances in Obesity Research II, pp. 211-228, (1978)

[5]

Jequier, Thermogenesis induced by nutrient administration in man, Infusionstherapie, 11, pp. 184-188, (1984)

[6]

Hayashida, Kido, Tsujinaka, Et al., Increased energy expenditure after intravenous administration of amino acids, JPEN, 16, pp. 142-148, (1992)

[7]

Steiger, Vars, Dudrick, A technique for long-term intravenous feeding in unrestrained rats, Arch Surg, 104, pp. 330-332, (1972)

[8]

Naruko, Ogawa, Kido, Et al., Studies on the energy expenditure following surgical stress. The effects of the severity of stress and the administration fo nutrients, Jpn J Surg, 18, pp. 194-202, (1988)

[9]

Lusk, Analysis of the oxidation of mixtures of carbohydrate and fat, J Biol Chem, 59, pp. 41-42, (1924)

[10]

Wilhot, Selected value of thermodynamic properties, Biochemical Microcalorimetry, pp. 306-315, (1969)

← 1 2 →