A P-31-MAGNETIC RESONANCE STUDY OF ANTEGRADE AND RETROGRADE CEREBRAL PERFUSION DURING AORTIC-ARCH SURGERY IN PIGS

被引:51
作者
FILGUEIRAS, CL
WINSBORROW, B
YE, J
SCOTT, J
ARONOV, A
KOZLOWSKI, P
SHABNAVARD, L
SUMMERS, R
SAUNDERS, JK
DESLAURIERS, R
SALERNO, TA
机构
[1] NATL RES COUNCIL CANADA,INST BIODIAGNOST,WINNIPEG,MB R3B 1Y6,CANADA
[2] UNIV TORONTO,ST MICHAELS HOSP,DIV CARDIOTHORAC SURG,TORONTO,ON M5B 1W8,CANADA
关键词
D O I
10.1016/S0022-5223(05)80009-1
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
To evaluate the effect of hypothermic circulatory arrest on brain metabolism, we used P-31-magnetic resonance spectroscopy to monitor brain metabolites in pigs during 2 hours of ischemia and 1 hour of reperfusion. Twenty-eight pigs were divided into five groups, Anesthesia (n = 5) and hypothermic cardiopulmonary bypass groups (n = 5) served as controls, In the circulatory arrest (n = 6), antegrade perfusion (n = 6), and retrograde (n = 6) brain perfusion groups, the bypass flow rate was 60 to 100 ml . kg(-1). min(-1). In the antegrade group, the brain was perfused via the carotid arteries at a blood flow rate of 180 to 200 ml . min(-1) during circulatory arrest at 15 degrees C. In the retrograde group, the brain was perfused through the superior vena cava at a flow rate of 300 to 500 ml . min(-1) during circulatory arrest at 15 degrees C. The intracellular pH was 7.1 +/- 0.1 and 7.3 +/- 0.1 in the anesthesia and hypothermic cardiopulmonary bypass groups, respectively, In the circulatory arrest group, the intracellular pH decreased to 6.2 +/- 0.1 and did not recover to its initial value (7.0 +/- 0.1) during reperfusion (p < 0.05 compared with the value obtained from the control groups at the corresponding time), Inorganic phosphate did not return to its initial level during reperfusion, In three animals in this group, levels of high-energy phosphates, adenosine triphosphate and phosphocreatine, recovered partially but did not reach the levels observed before arrest. In the group receiving antegrade perfusion, cerebral metabolites and intracellular pH were unchanged throughout the protocol, During circulatory arrest in the retrograde perfusion group the intracellular pH decreased to 6.4 +/- 0.1 and recovered fully during reperfusion (7.1 +/- 0.1), High-energy phosphates also returned to their initial levels during reperfusion, These studies show that deep hypothermic circulatory arrest with antegrade brain perfusion provides the best brain protection of the options investigated.
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页码:55 / 62
页数:8
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