PROGRAMMED CELL-DEATH INDUCED BY HIV TYPE-1 ANTIGEN STIMULATION IS ASSOCIATED WITH A DECREASE IN CYTOTOXIC T-LYMPHOCYTE ACTIVITY IN ADVANCED HIV TYPE-1 INFECTION

被引:13
作者
CHIA, WK
FREEDMAN, J
LI, XY
SALIT, I
KARDISH, M
READ, SE
机构
[1] HOSP SICK CHILDREN,DIV INFECT DIS,TORONTO,ON M5G 1X8,CANADA
[2] UNIV TORONTO,DEPT MICROBIOL,TORONTO,ON M5S 1A8,CANADA
[3] ST MICHAELS HOSP,DEPT HAEMATOL,TORONTO,ON M5B 1W8,CANADA
[4] TORONTO GEN HOSP,DIV INFECT DIS,TORONTO,ON M5G 2C4,CANADA
关键词
D O I
10.1089/aid.1995.11.249
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The immune competence of peripheral blood mononuclear cells (PBMCs)from human immunodeficiency virus-seropositive (HIV+) patients was studied by assessing cytotoxic T lymphocyte (CTL) activity following recall HIV antigen stimulation. Target cells were HLA-A-matched EBV-transformed B cells expressing HIV-1 antigen. In the presence of recombinant IL-2 (rIL-2, 2 or 10 U/ml), about 50% of PBMCs from HIV+ asymptomatic patients responded to HIV-1 antigen stimulation iii vitro with increased cytotoxic activity. In contrast, PBMCs from patients with overt AIDS, cultured in medium containing rIL-2 (2 U/ml) and HIV-1 antigen, showed no increase in cytotoxic activity; in the presence of rIL-2 (10 U/ml) and HIV-1 antigen, an inhibitory effect on CTL activity was observed. This inhibitory effect was associated with programmed cell death (apoptosis) of CD8(+) lymphocytes and cells of both gamma/delta TcR-positive and -negative phenotypes. However, prior to the apoptosis, different TcR phenotypes of T lymphocyte reacted differently to HIV-1 antigen stimulation. The HIV-1 antigen initially appeared to cause gamma/delta TcR-positive T lymphocytes to proliferate and/or differentiate and later induced cell death. Whereas, prior to the apoptosis, no proliferation of gamma/delta TcR-negative T lymphocytes induced by HIV-1 antigen was observed.
引用
收藏
页码:249 / 256
页数:8
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