ANTIMUTAGENICITY PROFILES FOR SOME MODEL COMPOUNDS

被引:253
作者
WATERS, MD
BRADY, AL
STACK, HF
BROCKMAN, HE
机构
[1] ENVIRONM HLTH RES & TESTING INC, RES TRIANGLE PK, NC 27709 USA
[2] ILLINOIS STATE UNIV, DEPT BIOL SCI, NORMAL, IL 61761 USA
来源
MUTATION RESEARCH | 1990年 / 238卷 / 01期
关键词
Activity profile listings; Antimutagenicity profiles; Model compounds; plots;
D O I
10.1016/0165-1110(90)90039-E
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
The concept of activity profile listings and plots, already applied successfully to the display of mutagenicity data, has been modified for application to antimutagenicity data. The activity profiles are bar graphs that have been organized in two general ways: for antimutagens that have been tested in combination with a given mutagen and for mutagens that have been tested in combination with a given antimutagen. Doses from both the mutagen and the antimutagen are displayed and plotted together with results on enhancement or inhibition of mutagenic activity. The short-term tests that have been used extensively to identify mutagens and potential carcinogens are increasingly being used to identify antimutagens and potential anticarcinogens. Three model mutagens, N-methyl-N′-nitro-N-nitrosoguanidine, aflatoxin B1 and benzo[a]pyrene, and 4 model antimutagens, butylated hydroxyanisole, butylated hydroxytoluene, glutathione and disulfiram, were selected from the data surveyed in the published literature. It is not clear at the present time whether the inhibition of carcinogen-induced mutation is a good indicator of anticarcinogenic properties, and further research is needed. Nevertheless, the activity profiles are useful for the assessment of the available antimutagenesis data by providing rapid visualization of considerable dose information and experimental results. © 1990.
引用
收藏
页码:57 / 85
页数:29
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