INSITU HYBRIDIZATION AND TRANSLOCATION BREAKPOINT MAPPING .3. DIGEORGE SYNDROME WITH PARTIAL MONOSOMY OF CHROMOSOME-22

被引：28

作者：

CANNIZZARO, LA

EMANUEL, BS

机构：

[1] CHILDRENS HOSP, DEPT PEDIATR & HUMAN GENET, 34TH ST & CIVIC CTR BLVD, PHILADELPHIA, PA 19104 USA

[2] UNIV PENN, DEPT PEDIATR & HUMAN GENET, PHILADELPHIA, PA 19107 USA

来源：

CYTOGENETICS AND CELL GENETICS | 1985年 / 39卷 / 03期

关键词：

D O I：

10.1159/000132131

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

We have performed in situ hybridization of a probe for the [human] .lambda. IGLC constant region to metaphase spreads from two DiGeorge syndrome (DGS)-related chromosomal rearrangements with breakpoints in 22q11. In this study we have demonstrated that the breakpoints are proximal to the .lambda. IGLC constant region cluster. Thus, at the molecular level, DGS-related breakpoints can be distinguished from the 22q11 breakpoint of CML, but not from the 8;22 translocation of Burkitt lymphoma or from the 21;22 translocations that we have previously studied.

引用

页码：179 / 183

页数：5

共 15 条

[1] AN IMPROVED METHOD FOR G-BANDING CHROMOSOMES AFTER INSITU HYBRIDIZATION
CANNIZZARO, LA
EMANUEL, BS
[J]. CYTOGENETICS AND CELL GENETICS, 1984, 38 (04): : 308 - 309
[2] INSITU HYBRIDIZATION AND TRANSLOCATION BREAKPOINT MAPPING .2. 2 UNUSUAL T(21-22) TRANSLOCATIONS
CANNIZZARO, LA
ARONSON, MM
EMANUEL, BS
[J]. CYTOGENETICS AND CELL GENETICS, 1985, 39 (03): : 173 - 178
[3] A DELETION IN CHROMOSOME-22 CAN CAUSE DIGEORGE SYNDROME
DELACHAPELLE, A
HERVA, R
KOIVISTO, M
AULA, P
[J]. HUMAN GENETICS, 1981, 57 (03) : 253 - 256
[4] INSITU HYBRIDIZATION AND TRANSLOCATION BREAKPOINT MAPPING .1. NONIDENTICAL 22Q11 BREAKPOINTS FOR THE T(9-22) OF CML AND THE T(8-22) OF BURKITT-LYMPHOMA
EMANUAL, BS
SELDEN, JR
WANG, E
NOWELL, PC
CROCE, CM
[J]. CYTOGENETICS AND CELL GENETICS, 1984, 38 (02): : 127 - 131
[5] CHROMOSOMAL ORIENTATION OF THE LAMBDA-LIGHT CHAIN LOCUS - V-LAMBDA IS PROXIMAL TO C-LAMBDA IN 22Q11
EMANUEL, BS
CANNIZZARO, LA
MAGRATH, I
TSUJIMOTO, Y
NOWELL, PC
CROCE, CM
[J]. NUCLEIC ACIDS RESEARCH, 1985, 13 (02) : 381 - 387
[6] ERIKSON J, 1981, NATURE, V294, P173, DOI 10.1038/294173a0
[7] QUANTITATIVE-ANALYSIS OF HIGH-RESOLUTION TRYPSIN-GIEMSA BANDS ON HUMAN PROMETAPHASE CHROMOSOMES
FRANCKE, U
OLIVER, N
[J]. HUMAN GENETICS, 1978, 45 (02) : 137 - 165
[8] FAMILIAL DIGEORGE SYNDROME AND ASSOCIATED PARTIAL MONOSOMY OF CHROMOSOME-22
GREENBERG, F
CROWDER, WE
PASCHALL, V
COLONLINARES, J
LUBIANSKI, B
LEDBETTER, DH
[J]. HUMAN GENETICS, 1984, 65 (04) : 317 - 319
[9] LOCALIZATION OF SINGLE COPY DNA-SEQUENCES ON G-BANDED HUMAN-CHROMOSOMES BY INSITU HYBRIDIZATION
HARPER, ME
SAUNDERS, GF
[J]. CHROMOSOMA, 1981, 83 (03) : 431 - 439
[10] THE ASSOCIATION OF THE DIGEORGE ANOMALAD WITH PARTIAL MONOSOMY OF CHROMOSOME 22
KELLEY, RI
ZACKAI, EH
EMANUEL, BS
KISTENMACHER, M
GREENBERG, F
PUNNETT, HH
[J]. JOURNAL OF PEDIATRICS, 1982, 101 (02) : 197 - 200

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